Bellen Shanghai – R&D CenterCDMO, Process R&D Center

Pre-clinical > Development

  • Innovative route design
  • Process optimization under well designed experiments
  • New technologies, e.g. flow chemistry, biocatalysis, photochemistry, applied to process chemistry
  • Development risk assessment performed for every step of manufacturing
  • “Know-How scale-up Library” built up for Bellen’s heterocycles
  • Quality awareness to meet the needs for drug development
  • Facilities adequately equipped to support process development

Key considerations

Economy

Cost-effective route design, increasign througput, reducing waste and disposal costs

Ecology

Choice of solvents and catalysts

Safety

Restricted use of class 1 solvents, low boiling or flash points, explosive reagents

 

 

Few facts

1300 + 1300 sqm lab and offices

2 glove boxes

1 NMR

6 UPLC

1 LC/MS

1 GC

1 ICP/OES

RC, DSC, Sedex, Redex

2x10L + 2x5L double layers jacket reactors + Huber unistat

Hydrogenation area

Low temperature area

Catalysts screening lab